Professor Eran Bacharach

Professor Eran Bacharach received his Bachelor of Science with distinction in Biology, Master of Science with distinction in Microbiology, and Ph. D in Microbiology from the Hebrew University in Jerusalem. 

Professor Bacharach has an interest in Molecular Virology with an emphasis on RNA viruses. He has done studies on many different areas including Murine Leukemia Virus (MLV), Human Immunodeficiency Virus (HIV), and Human Metapneumovirus (hMPV) among several different RNA studies. Professor Bacharach has also discovered an emerging novel RNA virus named TiLV as well as currently developing an oncolytic RNA virus that is efficient in the destruction of a subset of cancer cells. 

Professor Bacharach has received several awards over the years including The Rosansky Award at The Herbert Irving Cancer Center from Columbia University, The Dean’s Award for Outstanding Lecturer 6 times since 2007, The Sarov Prize in Microbiology at the Israel Society for Microbiology, and has one of the three top impactful research projects in the social and environmental domains, funded over 40 years by BARD, The US-Israel Binational Agricultural

Research and Development (BARD) Fund. 

  1. Publications (from the last ten years; * stands for a co-corresponding author):
  • Inferring protein function in an emerging virus: detection of the nucleoprotein in Tilapia Lake Virus. Abu Rass R, Kustin t, Zamostiano R, Smorodinsky N, Ben Meir D, Feder D, Mishra N, Lipkin WI, Eldar A, Ehrlich M, Stern A, Bacharach E. Journal of Virology. 2022 Accepted.
  • Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection. Katzman C, Israely T, Melamed S, Politi B, Sittner A, Yahalom-Ronen Y, Weiss S, Abu Rass R, Zamostiano R, Bacharach E, Ehrlich M, Paran N, Nissim L. Viruses. 2021 Dec 21;14(1):11.
  • Constitutive low expression of antiviral effectors sensitizes melanoma cells to a novel oncolytic virus. Dellac S, Ben-Dov H, Raanan A, Saleem H, Zamostiano R, Semyatich R, Lavi S, Witz IP, Bacharach E, Ehrlich M. Int J Cancer. 2021 May 1;148(9):2321-2334. 
  • Oncolytic Virotherapy: The Cancer Cell Side. Ehrlich M, Bacharach E. Cancers (Basel). 2021 Feb 24;13(5):939. 
  • Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics. Yankovitz G, Cohn O, Bacharach E, Peshes-Yaloz N, Steuerman Y, Iraqi FA, Gat-Viks I. Genetics. 2021 Apr 15;217(4):iyab016.
  • Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D. Diab M, Schmiedel D, Seidel E, Bacharach E, Mandelboim O. Viruses. 2020 Jul 20;12(7):781. 
  • Cell composition analysis of bulk genomics using single-cell data. Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E *, Gat-Viks I. Nat Methods. 2019 Apr;16(4):327-332. 
  • Predicting Phenotypic Diversity from Molecular and Genetic Data. Harel T, Peshes-Yaloz N, Bacharach E, Gat-Viks I. Genetics. 2019 Sep;213(1):297-311.
  • Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing. Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L, Cohn O, David E, Frishberg A, Mayo L, Bacharach E, Amit I, Gat-Viks I. Cell Syst. 2018 Jun 27;6(6):679-691.e4. 
  • Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. Danziger O, Pupko T, Bacharach E *, Ehrlich M. Front Immunol. 2018 Jan 30;9:94.
  • NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Diab M, Glasner A, Isaacson B, Bar-On Y, Drori Y, Yamin R, Duev-Cohen A, Danziger O, Zamostiano R, Mandelboim M, Jonjic S, Bacharach E, Mandelboim O. Eur J Immunol. 2017 Apr;47(4):692-703. 
  • Detection of Tilapia Lake Virus in Clinical Samples by Culturing and Nested Reverse Transcription-PCR. Kembou Tsofack JE, Zamostiano R, Watted S, Berkowitz A, Rosenbluth E, Mishra N, Briese T, Lipkin WI, Kabuusu RM, Ferguson H, Del Pozo J, Eldar A, Bacharach E. J Clin Microbiol. 2017 Mar;55(3):759-767.
  • Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1. Diab M, Vitenshtein A, Drori Y, Yamin R, Danziger O, Zamostiano R, Mandelboim M, Bacharach E, Mandelboim O. Oncotarget. 2016 Oct 11;7(41):66468-66479. 
  • Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. Bacharach E, Mishra N, Briese T, Zody MC, Kembou Tsofack JE, Zamostiano R, Berkowitz A, Ng J, Nitido A, Corvelo A, Toussaint NC, Abel Nielsen SC, Hornig M, Del Pozo J, Bloom T, Ferguson H, Eldar A, Lipkin WI. mBio. 2016 Apr 5;7(2):e00431-16. 
  • Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. Danziger O, Shai B, Sabo Y, Bacharach E *, Ehrlich M. Oncotarget. 2016 Aug 9;7(32):52115-52134.
  • Targeting the Early Step of Building Block Organization in Viral Capsid Assembly. Lampel A, Bram Y, Ezer A, Shaltiel-Kario R, Saad JS, Bacharach E, Gazit E. ACS Chem Biol. 2015 Aug 21;10(8):1785-90. 
  • α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments. Lampel A, Elis E, Guterman T, Shapira S, Marco P, Bacharach E, Gazit E. Chem Commun (Camb). 2015 Aug 11;51(62):12349-52. 
  • Dynamics and restriction of murine leukemia virus cores in mitotic and interphase cells. Elis E, Ehrlich M, Bacharach E. Retrovirology. 2015 Nov 14;12:95. 
  • New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M. Mol Cell Proteomics. 2015 Mar;14(3):532-43.
  • Identification of a novel RNA virus lethal to Tilapia. Eyngor M, Zamostiano R, Kembou Tsofack JE, Berkowitz A, Bercovier H, Tinman S, Lev M, Hurvitz A, Galeotti M, Bacharach E *, Eldar A. J Clin Microbiol. 2014 Dec;52(12):4137-46. 
  • The N-terminus of murine leukaemia virus p12 protein is required for mature core stability. Wight DJ, Boucherit VC, Wanaguru M, Elis E, Hirst EM, Li W, Ehrlich M, Bacharach E, Bishop KN. PLoS Pathog. 2014 Oct 30;10(10):e1004474.
  • Synonymous site conservation in the HIV-1 genome. Mayrose I, Stern A, Burdelova EO, Sabo Y, Laham-Karam N, Zamostiano R, Bacharach E, Pupko T. BMC Evol Biol. 2013 Aug 4;13:164. 
  • Epizootic hemorrhagic disease virus induces and benefits from cell stress, autophagy, and apoptosis. Shai B, Schmukler E, Yaniv R, Ziv N, Horn G, Bumbarov V, Yadin H, Smorodinsky NI, Bacharach E, Pinkas-Kramarski R, Ehrlich M. J Virol. 2013 Dec;87(24):13397-408. 
  • The effect of chemical chaperones on the assembly and stability of HIV-1 capsid protein. Lampel A, Bram Y, Levy-Sakin M, Bacharach E, Gazit E. PLoS One. 2013;8(4):e60867.  
  • A triclinic crystal structure of the carboxy-terminal domain of HIV-1 capsid protein with four molecules in the asymmetric unit reveals a novel packing interface. Lampel A, Yaniv O, Berger O, Bacharach E, Gazit E, Frolow F. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):602-6.
  • p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes. Elis E, Ehrlich M, Prizan-Ravid A, Laham-Karam N, Bacharach E. PLoS Pathog. 2012 Dec;8(12):e1003103. 
  • Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. Nachmias D, Sklan EH, Ehrlich M, Bacharach E. Retrovirology. 2012 Jan 19;9:7. 
  • The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production. Sabo Y, Ehrlich M, Bacharach E. J Virol. 2011 Jul;85(13):6594-609.