Professor Yankel Gabet

A. EDUCATION

 PERIODS OF STUDY

University / Institute:    Faculty of Medicine, The Hebrew University of Jerusalem, Israel

Subject:                         Years 1-3 Medical/Dental common curriculum

Period:                 1995-1998

Degree:   Bachelor of Science - B.Sc.   

Date Awarded:     1998

University / Institute:    Faculty of Medicine, The Hebrew University of Jerusalem, Israel

Subject:                         Dental Medicine

Period:                 1998-2001

Degree:   Doctoris Medicinae Dentariae - D.M.D.   

Date Awarded:     2002

University / Institute:     Bone Laboratory, Institute of Dental Sciences, The Hebrew University of Jerusalem, Israel.

Subject:                          Biomedical sciences, Bone fracture healing

Period:                            1998- 2001

Degree:                           Master of Sciences - M.Sc. – “Magna Cum Laude”  

Supervised by:               Prof. Itai Bab, Prof. Jona Sela and Prof. Arie Shteyer

Title of Thesis:               Osteogenic Growth Peptide (OGP) Enhances Early Stages of Fracture Healing in Rats: A Micro-Computed Tomographic, Biomechanical and Histomorphometric Analysis                    

Date Awarded:               2002

University / Institute:  Bone Laboratory, Institute of Dental Sciences, The Hebrew University of Jerusalem, Israel.

Subject:                           Biomedical sciences, Implantology

Period:                             2002-2007

Degree:                            Philosophiae Doctor - Ph.D.   

Supervised by:                Prof. Itai Bab, Prof. David Kohavi and Prof. Ralph Müller (ETH, Zürich)

Title of Doctoral Dissertation:   Anchorage of Titanium Implants in Low-Density Bone: Effect of Bone Anabolic Agents and Implant Surface Modulation                                                

Date Awarded:                 2008

B. FURTHER STUDIES 

University / Institute:     Oral Implantology Center, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel. 

Subject:                           Implant-Supported Prosthodontics

Period:                             2004-2007

Degree or Professional license: Certificate in Implant-Supported Prosthodontics, 

Date Awarded:                2008

Supervised by:               Prof. David Kohavi

University / Institute:     Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine; Departments of Urology, Microbiology, and Preventive Medicine, USC/Norris Comprehensive Cancer Center; University of Southern California

Subject:                           Bone and cancer biology

Period:                             2007-2010

Position:                          Post-Doctoral Fellow 

Supervised by:               Prof. Baruch Frenkel

Country

2011-2019

Israel

Sackler Faculty of Medicine, Tel Aviv University

Senior Lecturer

2014-2021

Israel

Sackler Faculty of Medicine, Institute for Advanced Studies, Tel Aviv University

Teaching committee member

2019-2023

Israel

Dept of Anatomy & Anthropology, Sackler Faculty of Medicine, Tel Aviv University 

Head of Department 

2019-

Israel

Sackler Faculty of Medicine, Tel Aviv University

Associate Professor

2020-

Israel

Sackler Faculty of Medicine, Tel Aviv University

Search committee member

Country

2002-

Israel

Private practice

Dentist

2010-2012

Israel

Magdent Ltd

Consultant

2015-2017

Israel

Kalytera Therapeutics Ltd

Senior Advisory Board member

2017-2019

Israel

EuroPacific Medical Ltd

Senior Advisory Board member

2020-2022

Israel

Osteop Ltd

Senior Advisory Board member

Date

Country

Subject &                                     name of conference

Role (*)

2000

Israel

Israel Calcified Tissues Society

Oral presentation

2002

Israel

International Association of Dental Research

Oral presentation

2002

Israel

Israeli Symposium on Computer-Aided Surgery

Oral presentation

2008

Spain

International Society for Bone Morphometry

Oral presentation

2008

Switzerland

European Calcified Tissue Society / Calcified Tissue International

Oral presentation

2008

Canada

American Society for Bone & Mineral Research (ASBMR)

2 oral presentations

2010

Canada

ASBMR

2 posters

2013

USA

ASBMR

PI on Poster presentation

2013

USA

American Society of Hematology (ASH)

PI on Poster presentation

2014

Israel

Israel Society for Physiology and Pharmacology

Invited speaker

2014

USA

ASBMR

PI on 3 Posters, 1 Oral presentation (1 award)

2014

USA

American Society of Hematology (ASH)

Oral presentation

2015

USA

Academy of Osseointegration

PI on poster selected among the top 12

2015

Israel

Israel Endocrinology Society

Reviewer and Session Chair

2015

Germany

10th International Lübeck conference

Leading PI on 1 Oral presentation, co-author on 2 others

2015

Israel

International Association for Dental Research

Session Chair, Leading PI on 2 Oral presentation, co-author on 1 other

2015

USA

ASBMR

Leading PI on 4 and Collaborator on 2 poster presentations

2016

Israel

Israel Society for Physiology and Pharmacology

Invited speaker + 4 posters

2016

USA

ASBMR

Invited speaker, abstract reviewer 

2016

Israel

Israeli Society for Skeletal Biology and Medicine

Chair of Steering Committee. Leading PI on 1 Oral presentation + 2 posters (1 award).

2017

Israel

FISEB (Ilanit)

Invited speaker + Poster

2017

Canada

International Cannabinoid Research Society

1 poster

2017

USA

ASBMR

2 posters

2018

Israel

Israeli Society for Skeletal Biology and Medicine

Steering Committee. Leading PI on 1 Oral + 3 poster presentations (1 award).

2018

Israel (inter-national)

AMIF (France-Israel medical & dental collaboration)

Invited speaker

2018

Israel (inter-national meeting)

Osteoclasts & Bone Resorption in Health & Disease (Weizmann Institute)

Invited speaker + 1 oral presentation by student

2019

Israel 

Bone metabolism session, the Israel Endocrine Society 

Session chair, Oral presentation

2019

USA

Jewish Federation (Boca, FL) and AFTAU

Invited speaker

2020

Israel

FISEB (Ilanit)

Oral + Poster by students

2020

France

European Calcified Tissue Society (ECTS)

Speaker + Poster by student – all presented as ePosters (COVID)

2020

Israel 

The Lautenberg Center for Immunology and Cancer Research; Israel-Canada Medical Research Institute

Invited Speaker

2020

Israel (Int’l)

Mathematics of the MusculoSkeleton: Post-Genome analysis for Bone Biology

Scientific committee chair, Keynote speaker

2021

USA

International Association for Dental Research

Invited Speaker

2021

China

International Symposium on Biomedical Engineering and Computational Biology

Invited Speaker

2021

Israel (Int’l)

Genetics and Bone Biology

Scientific committee chair, Keynote speaker

2021

Israel (Int’l)

COST-GemStone training

Organizer, Speaker

2022

Israel (Int’l)

The International Medical Cannabis Conference

Invited Speaker

2022

Israel

Israel Endocrinology Society

Speaker

2022

Ireland

International Cannabinoid Research Society

Oral presentation by PhD student

Years (period)

Name of Organization

2002-2004

European Calcified Tissue Society

2006-2008

AAAS (Science)

2003-

American Society for Bone & Mineral Research

2005-

EFI (dentists association) – President since 2013

2011-2014

Israeli Calcified Tissue Society (ICTS) - Secretary

2014-

Israeli Society for Skeletal Biology and Medicine (formerly ICTS) - Treasurer

2015-

Israeli Endocrine Society

2018-

International Cannabinoid Research Society (ICRS)

Years (period)

Name of Student

Subject of Dissertation

Academic Institute

Ph.D/ MD-PhD

In collaboration with

2015-2020

Bitya Raphael

Endogenous peptidic CB2 agonist

TAU

Ph.D.

2015-2020

Michal Eger

Inflammation induced by titanium particles and bacterial infection: Mechanism and new therapeutic approaches

TAU

Ph.D.

Prof David Kohavi (Emeritus)

2018-

Zamzam Awida

Use of a non-erythroid EPO-R agonist to discriminate between EPO’s skeletal and erythropoietic effects

TAU

Ph.D.

Prof Drorit Neumann

2019-

Ana Iden

Role of CB2 in skin and colon cancer development

TAU

PhD

2020-

Mohamad Massarweh

Cannabinoid treatment in fracture healing

TAU

PhD

2021-

Ida Kreychman

Role of CB2 agonists in septic shock

TAU

PhD

Years (period)

Name of Student

Subject of Thesis

Academic Institute

In collaboration with

2013-2016

Roei Levy

New genetic determinants of bone metabolism

TAU

2013-2015

Michal Eger

Peri-implantitis induced by titanium particles released by ultrasonic scaling of implant surfaces

TAU

Prof David Kohavi

2013-2016

Elinor Halperin

Krox20 in skeletal dimorphism

TAU

2014-2018

Iris Herscu

Morphometric analysis of dentin cusps of ancient teeth

TAU

Dr Rachel Sarig

2014-2018

Elias Sabbag

Roles of sex steroids and Krox20 in osteoclast apoptosis

TAU

2017-

Neta Rozovsky

Protein coating on titanium implants

TAU

Dropped-out after pregnancy

2018-2021

Loiza Brami

Bone density regulation by the gut microbiome

TAU

2020-2021

Ida Kreychman

Role of CB2 in cytokine storm and septic shock

TAU

Prof Dan Frankel

2019-2022

Dan Zyc

Identification of gut microbiome strains that affect bone density

TAU

2020-

Liana Yonis

CB2 agonists in inflammation

TAU

2021-

Veronika Lerman

CAR-T therapy for osteoporosis

TAU

Dr Anat Globerson-Levin

Years (period)

Name of Student

Subject

Academic Institute

In collaboration with

2013-2014

Oleg Dolkart

Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway

TAU

2014-2019

Sahar Hiram-Bab

The role of erythropoietin in bone biology

TAU

Years (period)

Name of Student

Subject

Academic Institute

In collaboration with

2019-2021

Yael-Ellie Rosensky DMD

Cannabidiol as a Potential Treatment for Osteogenesis Imperfecta

TAU

2019-2022

Uriel Kaspersky DMD

Detection of new genes affecting the density and thickness of mice's calvaria using Collaborative Cross mice

TAU

2019-2022

Avshalom Ashirie MD

Human Stapes Demographic Distribution

TAU

2019-2022

Carmel Shinar MD

Morphometrical Study of the Footplate of Human Stapes and Its Application in Otosclerosis Surgery

TAU

Years (period)

Investigator     ( indicate : Principal/other)

Name of partners

Subject

Granted by Institute/ Company(*)                    

Total Amount

(personal)

2008-2010

Post-doctoral trainee

Cross-talk Between Wnt and AR Signaling Pathways in Bone Cells

Arthritis Foundation

$100,000

2012-2017

Gabet (PI)

Sexual dimorphism in bone remodeling; role of Krox20 in the monocytic lineage. This project will elucidate the putative interaction between sex hormone signaling and Krox20 in the monocytic lineage

Israel Science Foundation

$370,000

2012-2013

Gabet (PI)

High resolution microcomputed tomography system for imaging and morphometric analysis of bone specimens from small animals

Israel Science Foundation (equipment)

$265,000

2012-2016

Gabet (PI)

Structural evaluation of meniscus prostheses

Active Implants Ltd. *

$15,920

2013-2014

Epstein (PI)

Gabet (co-PI)

Circulating osteoblast-lineage cells – a novel, simple diagnostic procedure to detect stress fractures

Israel Defense Army

$28,000

2013-2014

Shpack (PI)

Gabet (co-PI)

Biomechanical evaluation of thermoplastic aligners by way of von Mises strains and stereolithography layers

Turnheim Foundation

$4,600

2013-2015

Sterer (PI)

Gabet (co-PI)

Effect of scaling induced titanium particles on in vitro pro-inflammatory cytokine secretion by macrophages

Rothstein Foundation

$3,500

2015-2016

Gabet (PI)

Histone H4 and peptide agonist at CB2 cannabinoid receptor

American Society for Bone and Mineral research GAP Award

$50,000

2015-2016

Gabet (PI)

Development of a custom-made stapedial prosthetic device

Y.D. Investments *

$67,500

2015-2017

Gabet (PI)

Therapeutic potential of Cannabidiol and Cannabidiol-derived compounds in fracture healing

Kalytera Therapeutics Ltd *

$194,315

2016-2018

Drorit Neumann (PI), Gabet (co-PI)

Erythropoietin in multiple myeloma – improving outcome without compromising bone

Israel Cancer Association

$21,000

2016-2018

Gabet (PI)

Therapeutic potential of Cannabidiol and Cannabidiol-derived compounds in osteogenesis imperfecta

Kalytera Therapeutics Ltd *

$334,800

2017-2021

Gabet (PI)

Long term tonic activation of CB2 by an endogenous peptide

Israel Science Foundation

$343,000

2018-2021

Gabet (PI, coordinator)

With Drorit Neumann, Martina Rauner & Ben Wielockx

Pathophysiological impact of erythropoietin on bone density

German-Israel Foundation

$283,000

($70,750)

2017-2018

Gabet (PI)

Testing of a new medical formula in a bone healing model in rats

PharmaSeed Ltd *

$26,000

2018-2018

Gabet (PI)

Therapeutic potential of CBD in fracture healing

EuroPacific Medical Inc. *

$45,225

2019-2021

Gabet (PI(

Pan-cancer prevention by potentiating the immune system via specific activation of the endocannabinoid system

Emerson Collective Cancer Research Fund

$200,000

2019-2022

Gabet (PI)

Long term bone anabolic CAR therapy against space-induced bone loss

Ministry of Science & Technology

$165,375

2019-2020

Gabet (PI) with Drorit Neumann & Varda Shalev

Anemia and Osteoporosis in the frail elderly

Gassner Fund

$10,500

2020-2021

Drorit Neumann (PI), Gabet (co-PI)

Cannabinoid agonist raises hemoglobin levels: Implications for treating anemia in cancer

Israel Cancer Association

$22,700

2020-2022

Drorit Neumann (PI), Gabet (co-PI)

Implementation of a non-erythropoietic derivative of erythropoietin for improving skeletal outcome in multiple myeloma and myelodysplastic syndromes

Dotan Research Center

$200,000

2021-2022

Gabet (PI), with Anat Globerson

Bone anabolic CAR therapy for the treatment of Osteoporosis

Collaborative Biomedical Science (TAU)

$12,900

2021-2026

Gabet (PI)

Treatment of cytokine storm syndrome and septic shock using a peptide secreted by Osteoblasts

Israel Science Foundation

$451,600

2021-2021

Gabet (PI)

Assessment of the anti-inflammatory actions of UV-treated Spirulina extracts

Vaxa Ltd*

$6,200

Total 

$3,221,135

Total (since last promotion)

$869,275‬‬‬‬‬‬‬‬‬‬‬

Years (period)

Investigator     (indicate : Principal/other)Name of partners

Subject

Granted by Institute/Company                    

Total Amount

(personal)

2022-2025

Gabet (PI, Coordinator), 8 partners from Israel, Germany and Denmark, and 2 companies 

Anabolic CAR-T Induced Osteoporosis treatmeNt (ACTION)

EIC PathFinder Open

3.2 mi Euros

(629,100 Euros)

2022-2026

Gabet (PI) with Evgeny Weinberg (TAU) and Georgios Kotsakis (TX, USA)

Targeting inflammasome activation by titanium particles as a pathogenic mechanism inducing non-resolving bacteria-related peri-implant bone loss

BSF

$250,000

($143,635)